Table 4.
Threshold effect analysis of S100A11 on metabolic markers by using two-piecewise linear regression, stratified by gender
| Inflection points of HbA1c | Inflection points of DIO (the liver) | Inflection points of CIR | |||||||
|---|---|---|---|---|---|---|---|---|---|
| β | (95%CI) | P | β | (95%CI) | P | β | (95%CI) | P | |
| Male | > 11.24 | 0.16 (0.03, 0.29) | 0.0245 | > 5.49 | 200.77 (9.58, 391.96) | 0.0478 | > 7.44 | 23.70 (− 1.02, 48.42) | 0.0699 |
| ≤ 11.24 | − 0.51 (− 0.98, − 0.05) | 0.0388 | ≤ 5.49 | − 47.30 (− 143.29, 48.69) | 0.3414 | ≤ 7.44 | − 11.20 (− 37.60, 15.20) | 0.4122 | |
| Female | > 5.28 | 0.23 (− 0.04, 0.50) | 0.1076 | > 3.04 | 676.51 (− 65.08, 1418.11) | 0.0802 | > 2.85 | 113.93 (24.32, 203.54) | 0.0165 |
| ≤ 5.28 | − 0.13 (− 0.36, 0.09) | 0.2393 | ≤ 3.04 | − 51.17 (− 204.06, 101.73) | 0.5151 | ≤ 2.85 | − 14.30 (− 30.96, 2.35) | 0.0992 | |
Effect: HbA1c, DIo (the liver), CIR; cause: S100A11
Adjusted: glucose tolerance, age, BMI, WHR, 0.5hPPG/0.5hPPI/HbA1c/FPG/FPI