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. 2021 Oct 28;1(1):e32856. doi: 10.2196/32856

Table 2.

Trend changes in the relative search volumes of ulcerative colitis in 2016-2020.a

Country, year Period 1 Period 2 Period 3
Weeks Weekly percentage change (%) (95% CI) Weeks Weekly percentage change (%) (95% CI) Weeks Weekly percentage change (%) (95% CI)
United States, 2016 1-3 80.2b (40.1 to 131.8) 3-6 –19.5 (–37.4 to 3.6) 6-52 –0.2b (–0.4 to 0)
United States, 2017 1-53 0.2 (0 to 0.4) N/Ac N/A N/A N/A
United States, 2018 1-52 0.1 (–0.1 to 0.3) N/A N/A N/A N/A
United States, 2019 1-52 –0.3b (–0.4 to –0.1) N/A N/A N/A N/A
United States, 2020 1-16 –2.8b (–4.0 to –1.6) 16-24 3.7 (–0.3 to 7.8) 24-52 –0.5 (–0.9 to 0)
Worldwide, 2016 1-52 –0.3b (–0.6 to –0.1) N/A N/A N/A N/A
Worldwide, 2017 1-46 0.1 (0 to 0.2) 46-49 5.7 (–6.5 to 19.6) 49-53 –7.9b (–11.5 to –4.3)
Worldwide, 2018 1-52 0 (–0.1 to 0.1) N/A N/A N/A N/A
Worldwide, 2019 1-46 0 (–0.1 to 0.1) 46-52 –2.1 (–4.5 to 0.3) N/A N/A
Worldwide, 2020 1-52 0 (–0.4 to 0.3) N/A N/A N/A N/A

aPeriods were separated as Period 1-4, when the trend changes were statistically detected in the joinpoint regression analysis during the study period.

bSignificantly different from zero (P<.05).

cN/A: not applicable.