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. 2023 Feb 20;14:1118751. doi: 10.3389/fendo.2023.1118751

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Copyright © 2023 Shymotiuk, Froese, Werlein, Naasner, Szaroszyk, Kühnel, Jonigk, Blaner, Wende, Abel, Bauersachs and Riehle

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experimental paradigm and increase in body weight independent of VitA following HFD feeding. (A) Mice with homozygous Lrat germline deletion (Lrat ^-/-) and wildtype controls (Lrat ^+/+) were obtained by breeding mice with heterozygous Lrat germline deletion (Lrat ^+/-). Dietary treatment started at 8 weeks of age for a duration of 20 weeks total. (B) Body weight data are reported as mean values ± SE and represent a subgroup of a previously published animal cohort (14). Two-way ANOVA was performed to analyze differences by HFD feeding and VitA. Results of post-hoc analyses for each comparison are summarized by symbols as defined: # p<0.05 for HFD feeding, $ p<0.05 for VitA, and & p<0.05 for the interaction between HFD feeding and VitA. Body weight following 0 ($, &), 4 (#, &), 8 (#, &), 12 (#), 16 (#), and 20 (#) weeks of dietary feeding (n=17-18/group). *p < 0.05 vs. normocaloric diet same VitA availability, † p<0.05 vs. VitA sufficiency same caloric diet.