Table:

Consequences of polymorphisms and mutations in deiodinases and thyroid hormone transporter genes on serum thyroid hormone concentrations

	Serum T3	Serum T4	Serum reverse T3	TSH	Number of patients
Polymorphism
rs2235544 (DIOl)41	Free T3 increased	Free T4 decreased	Decreased	Unchanged	552
rs12095080 (DIOl)42,43	Total T3 increased	Unchanged	Unchanged	Unchanged	995; 156
rs11206244 (DIOl)42,43	Total T3 decreased	Free T4 increased	Increased	Unchanged	995; 156
rs225014 (DIO2)44	Free T3 decreased	Free T4 increased	NA	Unchanged	140
rs12885300 (DIO2)42,44	Unchanged	Unchanged	Unchanged	Unchanged	995; 140
rs6647476 (MCT8*)45	Free T3 and total T3 decreased	Unchanged	Unchanged	Unchanged	2057 men
rs5937843 (MCT8*)45,46	Unchanged	Free T4 decreased	Unchanged	Unchanged	2057 men; 97 men
rs14399 (MCTlO†)45	Unchanged	Unchanged	Unchanged	Unchanged	3238
rs17606253 (MCTlO†)47	Unchanged	Unchanged	NA	Unchanged	45
rs10444412 (OATPlCl ‡)45,48	Unchanged	Unchanged	Unchanged	Unchanged	3238; 1192
rs10770704 (OATPlCl‡)45,48	Unchanged	Unchanged	Unchanged	Unchanged	3238; 154
rs36010656 (OATPlCl‡)48	Unchanged	Unchanged	Increased	Unchanged	154
Mutation
DIOl 49	Unchanged	Unchanged	Increased	Increased	8
MCT8* (Allan-Herndon-Dudley syndrome)50	Increased	Decreased	Decreased	Unchanged	5

NA=not available. T₃=tri-iodothyronine. T₄=thyroxine. TSH=thyroid-stimulating hormone.

^*Also known as SLC16A2.

^†Also known as SLC16A10.

^‡Also known as SLCO1C1.