Figure 9.

KOR activity changes the frequency of mEPSCs in Drd1-MSNs after C48/80 treatment. A, Sample traces of mEPSCs recorded in Drd1-MSNs at NAc core from saline-treated and C48/80-treated mice before and during application of U50488 (1 μm). B, Summary of the effects of U50488 on the frequency of mEPSCs recorded from saline and C48/80 treated mice (n = 7–12 neurons, t₍₁₇₎ = 2.943, **p = 0.0091). C, Summary of the effects of U50488 on the amplitude of mEPSCs (t₍₁₇₎ = 0.1314, p = 0.8970). D, Same as A for mEPSCs obtained in the absence or presence of nor-NBI (0.1 μm) from saline-treated and C48/80-treated mice. E, Summary of the effects of nor-NBI on the frequency of mEPSCs recorded from saline-treated and C48/80-treated mice (n = 9–11 neurons, U = 14, **p = 0.0057). F, Summary of the effects of nor-NBI on the amplitude of mEPSC (t₍₁₈₎ = 0.3375, p = 0.7396).