TABLE 7.
MHC-like enhancement sites of orf1ab and N proteins
| Protein | Variant | Code | Mutation site | MHC-like enhancement site |
|---|---|---|---|---|
| orf1ab | Alpha | B.1.1.7 | nsp3:T183I, nsp3:A890D, nsp3:I1412T, nsp6:SGF106-108, RdRp:P323L | — |
| Beta | B.1.351 | nsp2:T85I, nsp3:K837N, 3CL:K90R, nsp6:SGF106-108, RdRP:P323L | — | |
| Gama | P.1 | nsp3:S370L, nsp3:K977Q, nsp6:SGF106-108, RdRP:P323L, nsp13: E341D | — | |
| Delta | B.1.617.2 | nsp3:A488S, nsp3:P1228L, nsp3:P1469S, nsp4:V167L, nsp4:T492I, nsp6:T77A, RdRP:P323L, RdRP: G671S, nsp13:P77L, nsp14:A394V | RdRP: G671S (MHC_I-like_Ag-recog C) | |
| Lambda | C.37 | nsp3:T428I, nsp3:P1469S, nsp3:F1569V, nsp4:L438P, nsp4:T492I, 3CL:G15S, nsp6:SGF106-108, RdRP:P323L | nsp3:F1569V(MHC_II_beta B, MHC_I-like_Ag-recog E) | |
| N | Alpha | B.1.1.7 | D3L, R203K, G204R, S235F | — |
| Beta | B.1.351 | T205I | — | |
| Gama | P.1 | P80R, R203K, G204R | — | |
| Delta | B.1.617.2 | D63G, R203M, G215G,D377Y | D63G (MHC_II_beta A, MHC_I-like_Ag-recog A) | |
| Lambda | C.37 | P13L, R203K, G204R, G214C | — |
MHC indicates major histocompatibility complex.