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. 2023 Feb;44(2):137–144. doi: 10.15537/smj.2023.44.2.20220617

Figure 3.

Figure 3

- Regulation of sevoflurane and propofol on blood macrophages long noncoding RNA-GAS5 levels and M1 polarization in Ins genotype and Del genotype. (A) Del genotype (n=3) or (B) Ins genotype (n=3) peripheral blood derived macrophages were pre-exposed by 5% sevoflurane/propofol, followed by lipopolysaccharide (200ng/mL) treatment for 24 hours (h). LncRNA-GAS5 levels were determined by qRT-PCR assay. (C-E) Del genotype peripheral blood derived macrophages were transfected with or without LncRNA-GAS5-OV for 24 h, then were pre-exposed by 5% sevoflurane/propofol, followed by LPS (200ng/mL) treatment for another 24 h. (C) IL-6, and (D) TNF-α levels were determined.