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Severe bleeding in the cranial mesenchyme of fibulin-1-deficient E13.5 embryos with leaking venous plexus. (A) A sinus venosus, next to the rupture, is leaking erythrocytes, as shown by HE staining. (B and C) Immunofluorescence of serial sections with antibodies against PECAM-1 (B) and perlecan (C) revealed multiply disrupted endothelial cell layers (arrows) in the same region. Erythrocytes were made visible in panels B and C by superimposing their autofluorescence. Bar, 50 μm.
