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. 2023 Mar 6;18(3):e0282569. doi: 10.1371/journal.pone.0282569

Fig 2. TRPA1 blockade improves non-TDI models of atopic dermatitis.

Fig 2

(A) Overview of MC903 model where topical application occurred daily for 8 days before topical Roseomonas mucosa, cardamonin (Card), or ground cardamom seeds (Spice) were applied for three days. Ears were assessed 3 days after treatment; resultant ear thickness (B) and representative histology (C) are shown (N = 8–19 per group with each dot representing one mouse). (D) R. mucosa was grown in broth with either diluent, cardamonin or ground cardamom seeds (N = 1 isolate in triplicate wells). Resultant impact on optical density is shown. Data represent a combination of (B) or representative of (C-D) two or more independent experiments and are displayed as mean+SEM. ns = not significant, * = p <0.05, ** = p <0.01, *** = p <0.001, **** = p<0.0001 as determined by ANOVA for all displayed items.