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. 2023 Feb 23;51(1):331–342. doi: 10.1042/BST20220833

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© 2023 The Author(s)

This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY). Open access for this article was enabled by the participation of Queen's University Belfast in an all-inclusive Read & Publish agreement with Portland Press and the Biochemical Society under a transformative agreement with JISC.

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Figure 3. — Activation of CaMKK2 via its interaction with Ca²⁺/calmodulin results in the activation of downstream signalling pathways through kinases AMPK, CaMKI, CaMKIV and protein kinase B (PKB). This drives functions related to metabolic regulation and transcriptional regulation. In addition to these activities, CaMKK2 regulates multiple membrane trafficking pathways, which include autophagy, clathrin-mediated endocytosis and Golgi vesicle trafficking. Regulation of these membrane trafficking pathways is important for cellular control of metabolism and cell survival. Figure created with BioRender.com.