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. 2023 Feb 6;12:e80500. doi: 10.7554/eLife.80500

Table 1. Top enrichment results of muscle-related modules not driven by cell type composition.

Module Term FDR #Enriched genes Hub genes
Higher expression in G1 (GR, STM, and STD)
M.30 (75 genes) IRE1-mediated unfolded protein response 4×10–4 4
M.32 (236 genes) Hormone-mediated signaling pathway 9×10–3 11 CARM1, WBP2, ZBTB7A
M.7 (308 genes) Negative regulation of nucleobase-containing compound metabolic process 6×10–4 51 CREBBP, DAB2IP, FOXK2, LARP1, RXRA, THRA
Chromatin organization 1×10–2 27 ARID1B, CREBBP, HUWE1
M.17 (176 genes) Chromatin modifying enzymes 4×10–3 11 HCFC1, SETD1A
Higher expression in G2 (RF, VL, and VM) and G3 (GL)
M.31 (945 genes) RNA splicing 6×10–5 54 SNRNP70
Histone modification 3×10–3 47 KAT2A
M.33 (538 genes) Apical junction complex 2.4×10–2 11 MICALL2
M.13 (300 genes) Mitochondrion 4×10–45 122 AIFM1, ATP5F1A, ATP5F1B, CKMT2, COQ9, DLD, DLST, FH, GHITM, HADHA, HADHB, IMMT, MFN2, NDUFS2, PDHA1, PDHB, TRAP1, UQCRC2
M.14 (162 genes) Anterior/posterior pattern specification 4×10–3 7 HOXA11
Higher expression in G3 (GL)
M.5 (190 genes) Regulation of lipid metabolic process 8×10–4 15 ADIPOQ, ADRA2A, CIDEA, LEP, LGALS12, PDE3B, SCD
M.25 (188 genes) Ameboidal-type cell migration 5×10–3 15 CFL1, PML, TGFB1
Positive regulation of muscle cell differentiation 9×10–3 6 EHD2, ENG, NIBAN2, TGFB1
M.11 (299 genes) Golgi membrane 2×10–3 30 ASAP2, MAN1A1
Regulation of nervous system development 8×10–3 30 IQGAP1