Figure 3. Continuous relationships between amyloid biomarkers and functional connectivity (FC-brain age gap [BAG]; A and B), structural (S-BAG; C and D), and multimodal (S+FC BAG; E and F) BAG in the analysis sets.

Scatterplots show amyloid PET (A, C, and E) and CSF AB42/40 (B, D, and F) as a function of residual BAG (controlling for true age) in each group. Colored lines and shaded areas represent group-specific regression lines and 95% confidence regions. Dashed black lines represent main effect regression lines across all groups.