TABLE 2.
Baseline demographic and laboratory markers of the study population
| Alcohol use disorder—M. restricta negative (n=36) | Alcohol use disorder—M. restricta positive (n=30) | p | |
|---|---|---|---|
| Sex (male), n (%) | 24 (67) | 23 (77) | 0.37 |
| Age (y), n=66 | 45.0 (19.5) | 42.0 (15.0) | 0.83 |
| Body mass index (kg/m2), n=66 | 24.3 (4.9) | 23.7 (6.2) | 0.72 |
| AST (IU/L), n=66 | 33 (37.25) | 59 (75.5) | 0.18 |
| ALT (IU/L), n=66 | 28 (32.5) | 56 (50.0) | 0.028 |
| GGT (IU/L), n=65 | 49 (154) | 120.5 (222.5) | 0.027 |
| AP (IU/L), n=64 | 66 (31.5) | 76 (20) | 0.11 |
| Bilirubin (mg/dL), n=66 | 0.50 (0.25) | 0.45 (0.30) | 0.31 |
| Albumin (g/dL), n=63 | 4.6 (0.63) | 4.6 (0.5) | 0.80 |
| INR, n=65 | 1.0 (0.1) | 1.0 (0.2) | 0.94 |
| Creatinine (mg/dL), n=66 | 0.80 (0.16) | 0.82 (0.15) | 0.38 |
| Platelets (109/L), n=66 | 213 (85) | 238 (107) | 0.35 |
| CK18-M65 (U/L), n=63 | 251.0 (328.2) | 458.4 (456.2) | 0.011 |
Notes: Values are presented as median and interquartile range in parentheses. The number of subjects for which data were available is indicated in the first column. Continuous variables were compared using the Mann-Whitney test. Categorical variables were compared using the Pearson Chi-squared test. Bold font indicates statistical significance (p <0.05).
Abbreviations: ALT, alanine aminotransferase; AP, alkaline phosphatase; AST, aspartate aminotransferase; CK18-M65, caspase-cleaved and intact cytokeratin 18; GGT, gamma-glutamyltransferase; INR, international normalized ratio; M. restricta, Malassezia restricta.