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CIITA suppresses other promoters. The effect of CIITA on the IL-4 promoter (A), the TK promoter (B), and the cyclin D1 promoter (C) are shown. The IL-4 CAT reporter gene was transiently cotransfected with an empty vector (panel A, left-hand graph, lane 1), wild-type (wt) CIITA (same graph, lane 2), or CIITA(59-94)Δ (same graph, lane 3). The other two reporter constructs were only cotransfected with either CIITA or an empty vector.
