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(a) Cross-reactivity profile of 11 antibodies evaluated by ELISA, showing they are cross-reactive to human and cyno uPAR, and 2G10 and 3C6 are specific binders for human uPAR. (b) ADCC activity of 11 antibodies and 2G10 in the presence of NK-92® MI CD16a effector cells against MDA-MB-231 cells. Two-way ANOVA followed by posthoc tukey test reveals significant activity over human isotype IgG1 (hIgG1). * = p≤0.001.
