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(a) BLI epitope binning of three lead antibodies and vitronectin to uPAR. The binding of each antibody to uPAR resulted in a decreased wavelength shift in the last association step (VN-added) demonstrating the competitive blocking of VN binding by each antibody. (b) BLI competition assay reveals 8163 and 3159 have distinct binding sites, and 11857 has a partially overlapping epitope with 8163 and 3159.
