Table 2.
Exposures | SNPs | Methods | OR | 95% CI | P * |
---|---|---|---|---|---|
Adiponectin | 13 | Inverse variance weighted | 0.990 | 0.984–0.997 | 2.66 × 10−3 |
MR Egger | 0.983 | 0.975–0.992 | 3.47 × 10−3 | ||
Weighted median | 0.989 | 0.980–0.997 | 0.01 | ||
Weighted mode | 0.987 | 0.979–0.996 | 0.01 | ||
BMI | 145 | Inverse variance weighted | 0.987 | 0.980–0.994 | 5.98 × 10−4 |
MR Egger | 1.009 | 0.988–1.031 | 0.36 | ||
Weighted median | 0.992 | 0.984–1.001 | 0.08 | ||
Weighted mode | 0.992 | 0.970–1.014 | 0.51 | ||
Fasting blood glucose | 22 | Inverse variance weighted | 1.007 | 0.995–1.019 | 0.28 |
MR Egger | 0.986 | 0.963–1.009 | 0.25 | ||
Weighted median | 1.007 | 0.995–1.019 | 0.24 | ||
Weighted mode | 0.998 | 0.987–1.009 | 0.73 | ||
Fasting insulin | 14 | Inverse variance weighted | 1.007 | 0.971–1.044 | 0.70 |
MR Egger | 0.810 | 0.690–0.951 | 0.02 | ||
Weighted median | 1.015 | 0.979–1.052 | 0.43 | ||
Weighted mode | 1.068 | 0.995–1.147 | 0.09 | ||
HbA1c | 213 | Inverse variance weighted | 1.022 | 1.011–1.032 | 3.06 × 10−5 |
MR Egger | 1.033 | 1.002–1.066 | 0.04 | ||
Weighted median | 1.012 | 1.001–1.024 | 0.03 | ||
Weighted mode | 1.008 | 0.981–1.036 | 0.57 | ||
Proinsulin levels | 8 | Inverse variance weighted | 1.006 | 0.996–1.015 | 0.24 |
MR Egger | 0.995 | 0.974–1.018 | 0.69 | ||
Weighted median | 1.005 | 0.996–1.013 | 0.28 | ||
Weighted mode | 0.999 | 0.990–1.010 | 0.99 |
Significance was defined as P < 8.3 × 10−3.