Figure 1.

Establishment of the fungal keratitis mouse model. (A) Mouse corneas were observed and photographed at 1, 3, and 5 days post infection (dpi). (B) The clinical pathology score was assessed in each group. Two-way ANOVA followed by Tukey's HSD post hoc test was performed to assess differences in clinical score (***, P < 0.001 versus the control group; ###, P < 0.001 versus the FK1 group). (C) IVCM was used to diagnose the FK in mouse model. (D) Representative corneal sections from control and FK model mice were stained with hematoxylin and eosin (H&E, 400 times magnification ) for histological evaluation. Arrows showed the fungal hyphae. FK, fungal keratitis.