Study cohort schematic. (A) In this study, 465 participants in the PROGRESSA cohort successfully completed the 7-day study period. Following review of SD-OCT imaging, the rates of macular GCIPL thinning were correlated with recorded mean daily steps in 735 eyes from 388 participants. (B) In the secondary analysis, 96,679 participants of the UK Biobank successfully completed the physical activity study. Of the potential 193,358 eyes of this cohort, 11,051 eyes had available macular thickness data. A further 2189 eyes (n = 1547 participants) were then excluded due to unavailable comorbidity or demographic data, leaving 8862 eyes from 6152 participants for analysis.