Figure 1.

Summary of qualitative light–dark changes in WT and 5xFAD mice. (A) Representative OCTs of WT (top) and 5xFAD (bottom) mice retina. ONL, outer nuclear layer; ELM, external limiting membrane; EZ, inner segment ellipsoid zone; RPE, retinal pigment epithelium. (B) Representative reflectivity (or signal intensity) profile, also known as the A-line (green arrow), in a light-adapted WT mouse (top) and a 5xFAD mouse (bottom). The 5xFAD mouse has visibly appreciable thinning of its ELM-RPE region (black double-headed arrows), a lower HB intensity (red), and rounder EZ (shown in pink); together, these changes imply a higher energy demand in 5xFAD rods. WT and 5xFAD A-line profiles are scaled the same; no y-axis is shown because units are arbitrary. No signal intensity normalization was performed for these indices.