Figure 2.

Summary of quantitative light–dark changes in bioenergy OCT biomarkers within controls (left two columns) and within 5xFAD (right two columns) groups. As expected, in controls, light produced a more elongated EZ reflectivity profile shape (A), a thicker ELM-RPE (C), and higher HB intensity (E) panretinally compared to those in the dark. In contrast, in light versus dark-adapted 5xFAD mice, EZ aspect ratios were not different (B), ELM-RPE was thinner (D), and HB intensity was only significantly lower on the inferior side (F). Black horizontal line indicates P < 0.05 (two-tailed, linear mixed-model analysis; mean ± 95% confidence interval [CI]); n = 5 WT, n = 5 5xFAD. Individual data points represent the measured value for each mouse.