Figure 3.

Summary of quantitative light–dark changes in bioenergy OCT biomarkers between control and 5xFAD mice. In the light (left two columns), 5xFAD mice showed a rounder EZ reflectivity profile shape (A), a thinner ELM-RPE that reached significance only on the superior side (C), and lower HB intensity compared (E) to controls. In the dark, no significant differences between controls and 5xFAD mice were noted in EZ reflectivity profile shape (B), ELM-RPE thickness (D), or HB intensity (F). Black horizontal line indicates P < 0.05 (two-tailed, linear mixed-model analysis; mean ± 95% CI); n = 5 WT, n = 5 5xFAD. Individual data points represent the measured value for each mouse.