Figure 4.

Summary of retinal layer thickness changes between controls and 5xFAD mice; results in light and dark were similar but only the results for light are shown for clarity. (A) Compared to controls, 5xFAD showed laminar thinning for ONL but only reached significance on the superior side. (B) INL+OPL, thinning was not significantly different between inferior and superior sides and results were averaged. (C) IPL did not differ significantly between groups. (D) RFNL was greater than normal in 5xFAD mice and did not differ significantly on inferior and superior sides; results are averaged. (E) The whole retina showed significant thinning limited to the superior side. Black horizontal line indicates P < 0.05 (two-tailed, linear mixed-model analysis; mean ± 95% CI); n = 5 WT, n = 5 5xFAD. Individual data points represent the measured value for each mouse.