Table 2.
Common and prognostic copy number alterations in meningiomas
| Chromosome arm/gene | Loss/Gain | Approximate frequency in all meningiomas | Contribution to clinical outcome |
|---|---|---|---|
| 1p | Loss | 30–50% | Unfavourable |
| 3q | Loss | 10–15% | Unfavourable |
| 4p | Loss | 5–10% | Unfavourable |
| 6p | Loss | 10% | Unfavourable |
| 6q | Loss | 15–20% | Unfavourable |
| 7p | Loss | 5% | Unfavourable |
| 8p | Gain | < 5% | Unknown |
| 10q | Loss | 10% | Unfavourable |
| 11q | Loss | 5% | Unfavourable |
| 14q | Loss | 20% | Unfavourable |
| 15q | Gain | < 5% | Unknown |
| 16q | Gain | 5% | Unknown |
| 17q | Gain | 5–10% | Unknown |
| 18q | Loss | 15–20% | Unfavourable |
| 20q | Gain | 10% | Unknown |
| 22q | Loss | 50–60% | Unfavourable |
| CDKN2A/B | Loss (homozygous) | 1–5% | Unfavourable |