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. 2023 Mar 6;13:3681. doi: 10.1038/s41598-023-30682-0

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Venn diagram of common differentially expressed genes (DEGs) between groups. The three circles represent energy metabolism-associated genes, inflammation-associated genes, and DEGs. The intersecting regions of the circles indicate the intersecting genes of different groups. (B) Proteins interacting with inflammation- and energy metabolism-associated genes. The protein–protein interaction network of DEGs was visualized using Cytoscape (version 3.9.1) according to its topological properties. The higher the color intensity and the lower the distance to the center, the more the number of genes it interacted with in the network. The hub sub-networks were screened by the MCODE plug-in. (C) Relaxin signaling pathway (www.kegg.jp/entry/map04926). Red and green boxes represent DEGs that were significantly up or downregulated in this pathway, respectively. (D) PI3K-Akt signaling pathway (www.kegg.jp/entry/map04151). Red and green boxes represent DEGs that were significantly up or downregulated in this pathway, respectively.