TABLE 1.

Summary of relevant information for three sites undertaking economic evaluations for ACCESS Open Minds.

Exposed population and comparators	AOM intervention* start/end dates	Service utilization	Costs	Study design and key elements	Data sources (location)	Sensitivity analysis
Eskasoni First Nation, NS Exposed: Youth aged 11–25 years Historical Control: EMHS users from January 1, 2012 to July 20, 2016 Parallel control: non-EMHS users from January 1, 2012 to December 31, 2020	July 20, 2016 to December 31, 2020	• Number of referrals seen at site • Number of visits at site • Number of ER visits • Number of hospital admissions • Number of inpatient days • Number of outpatient psychiatry visits and services • Number of non-psychiatry visits	• Total cost of AOM implementation • Total cost of hospital admissions • Total cost of ER visits • Total cost of physicians visits	ROI (costs generated by the intervention will be compared to costs under control condition)	• Eskasoni Mental Health Services (local site) • Mi’kmaw Client Linkage Registry data (Medavie Blue Cross) • Health Data Nova Scotia linked datasets: DAD, MED+, NARCS, MASTER++ (Provincial)	• Pre-post parallel trend assumption will be evaluated by examining the interaction between time and intervention • Time horizon over which the difference-in-differences are calculated will be varied • Analyses will be reconducted with inclusion of a washout period
Chatham-Kent, ON Exposed: Youth aged 11–25 years residing in Chatham-Kent from October 2016 to March 2020 Historical Control: Youth in Chatham- Kent catchment from October 1, 2012 to September 30, 2016 Parallel control: Youth in Sarnia catchment from October 1, 2012 to March 17, 2020	October 1, 2016 to March 17, 2020	• Number of referrals seen at site • Number of visits at site • Number of ER visits • Number of hospital admissions • Number of inpatient days • Number of outpatient psychiatry visits and services • Number of non-psychiatry visits covered under OHIP	• Total cost of AOM implementation and CMHA services • Total cost of hospital admissions • Total cost of ER visits • Total cost of physicians visits • Total cost of medications	ROI (costs generated by the intervention will be compared to costs under control condition) Time Horizon: no limit, repeated cross-sections of 6 months between October 1, 2012 and March 17, 2020 Washout period: 6 months before/after October 1, 2016	• Canadian Mental Health Association-Chatham-Kent (local site) • ICES linked datasets for cost analysis: ESTSOB, CCRS, HCD, DAD, NACRS, NRS, ODB, OHIP, OMHRS, SDS, ADP, CAPE, (provincial) • Additional ICES linked datasets for cohort description: CONTACT, RPDB, CPDB, IPDB, ONMARG, INST	• Pre-post parallel trend assumption will be evaluated by examining the interaction between time and intervention • Models will be re-run after excluding individuals with out-of-catchment service use • Analysis will be reconducted with removal of the washout period
Edmonton, AB AOM users, age 15–25 years Parallel control: Mental health service users from non-AOM community mental health clinics	April 6, 2017 to September 30, 2018	• Number of hospitalizations • Numbers of outpatient visits (ED, clinic, specialist, GP, CMHC) • Prescription drug usage • Residential admissions	• Total cost of AOM implementation • Total cost of hospital admissions • Total cost of ED, outpatient, specialist, GP, CMHC visits • Total cost of residential admissions • Total cost of physicians visits	ROI (costs generated by the intervention will be compared to costs under control condition) Time Horizon: Outcomes and costs were estimated for 1 year from the date of access to the AOM or control service, up to September 30, 2019	• Alberta Health Services (AHS) Mental Health and Addictions patient service data and associated costs • AHS community visit and residential stay data, and unit costs • Alberta Health (AH) hospital discharge data, outpatient visit data using CIHI case mix categories and associated costs • Alberta Health physician service data and Schedule of Medical Benefits • Alberta Health pharmaceutical data and unit costs	• Inclusion of all service types regardless of their statistical significance • Deterministic and probabilistic sensitivity analyses • Analysis will be reconducted with inclusion of a washout period

ADP, Assistive Devices Program; AHCIP, Alberta Health Care Insurance Plan; AHS, Alberta Health Services; AOM, ACCESS Open Minds; CAPE, Client Agency Program Enrolment; CCRS, Continuing Care Reporting System; CMHA LK, Canadian Mental Health Association Lambton Kent; CMHC, Community Mental Health Center; CONTACT, Yearly Health Services Contact; CPDB, Corporate Provider Database; DAD, Discharge Abstract Database; EMHS, Eskasoni Mental Health Services; ER, Emergency Room; ESTSOB, Estimated Schedule of Benefits; HCD, Home Care Database; HDNS, Health Data Nova Scotia; ICES, Institute for Clinical Evaluative Sciences; INST, Information about Ontario health care institutions funded by the Ministry of Health and Long-Term Care (MOHLTC); IPDB, ICES Physician Database; MCLR, Nova Scotia Mi’kmaw Client Linkage Registry; MHS, Mental Health Services; NACRS, National Ambulatory Care Reporting System; NRS, National Rehabilitation Reporting System; ODB, Ontario Drug Benefit Claims; OHIP, Ontario Health Insurance Plan Claims Database; OMHRS, Ontario Mental Health Reporting System; ONMARG, Ontario Marginalization Index; PIN, Pharmaceutical Information Network; ROI, Return on Investment; RPDB, Registered Persons Database; SDS, Same Day Surgery Database. *ACCESS Open Minds is the intervention in all three sites (reference)- the start and end dates reflect the economic evaluation, not necessarily the main AOM project. ⁺ MED, MSI Physician’s Billings. ⁺⁺ MASTER, Insured Patient Registry. Box 1 Study interventions.