TABLE 1.
Variants associated with age related hearing loss.
| Combined | Females | Males | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| H-both | Variant | Pos | Locus | A1 | Info | Freq | Beta (OR) | SE | P | N | Beta (OR) | P | N | Beta (OR) | P | N | |
| rs186256023 | 152067381 | ZNF185 | C | 0.92 | 0.03 | 0.08 (1.083) | 0.01 | 4.9E-10 | 330,558 | 0.11 (1.116) | 8.6E-07 | 182,676 | 0.07 (1.072) | 6.4E-06 | 147,882 | ||
| rs4370706 | 20,102,906 | MAP7D2 | T | 0.99 | 0.18 | 0.03 (1.030) | 0.01 | 2.3E-08 | 330,558 | 0.05 (1.051) | 6.4E-08 | 182,676 | 0.02 (1.020) | 2.5E-03 | 147,882 | ||
| rs7882991 | 20,054,650 | MAP7D2 | A | 0.98 | 0.18 | 0.03 (1.030) | 0.01 | 3.4E-08 | 330,558 | 0.05 (1.051) | 3.3E-08 | 182,676 | 0.02 (1.020) | 4.2E-03 | 147,882 | ||
| rs10081918 | 20,053,979 | MAP7D2 | T | 0.98 | 0.18 | 0.03 (1.030) | 0.01 | 3.6E-08 | 330,558 | 0.05 (1.051) | 3.1E-08 | 182,676 | 0.02 (1.020) | 4.4E-03 | 147,882 | ||
| rs5955880 | 20,084,743 | MAP7D2 | A | 0.99 | 0.18 | 0.03 (1.030) | 0.01 | 3.9E-08 | 330,558 | 0.06 (1.062) | 2.2E-08 | 182,676 | 0.02 (1.020) | 5.2E-03 | 147,882 | ||
| rs6527961 | 20,109,072 | MAP7D2 | A | 0.99 | 0.18 | 0.03 (1.030) | 0.01 | 3.9E-08 | 330,558 | 0.06 (1.062) | 2.3E-08 | 182,676 | 0.02 (1.020) | 5.1E-03 | 147,882 | ||
| rs12009531 | 20,074,441 | MAP7D2 | A | 0.99 | 0.18 | 0.03 (1.030) | 0.01 | 4.0E-08 | 330,558 | 0.06 (1.062) | 2.4E-08 | 182,676 | 0.02 (1.020) | 5.2E-03 | 147,882 | ||
| rs7062127 | 20,061,058 | MAP7D2 | G | 0.98 | 0.18 | 0.03 (1.030) | 0.01 | 4.0E-08 | 330,558 | 0.05 (1.051) | 8.9E-08 | 182,676 | 0.02 (1.020) | 3.6E-03 | 147,882 | ||
| rs60849679 | 20,116,215 | MAP7D2 | A | 1 | 0.18 | 0.03 (1.030) | 0.01 | 4.5E-08 | 330,558 | 0.05 (1.051) | 3.7E-08 | 182,676 | 0.02 (1.020) | 4.1E-03 | 147,882 | ||
| rs5955882 | 20,110,340 | MAP7D2 | T | 0.98 | 0.18 | 0.03 (1.030) | 0.01 | 5.7E-08 | 330,558 | 0.06 (1.062) | 2.7E-08 | 182,676 | 0.02 (1.020) | 6.4E-03 | 147,882 | ||
| rs7064198 | 20,101,842 | MAP7D2 | T | 0.99 | 0.18 | 0.03 (1.030) | 0.01 | 5.3E-08 | 330,558 | 0.06 (1.062) | 2.9E-08 | 182,676 | 0.02 (1.020) | 6.1E-03 | 147,882 | ||
| H-aid | rs138497700 | 112,591,946 | LOC101928437 | G | 0.83 | 0.003 | 2.00 (7.39) | 0.58 | 4.1E-04 | 252,895 | −1.17 (0.310) | 0.228 | 148,632 | 2.6 (13.46) | 8.9E-09 | 104,263 | |
| rs141853173 | 112,449,530 | LOC101928437 | T | 0.84 | 0.003 | 1.85 (6.36) | 0.61 | 4.3E-04 | 252,895 | −0.89 (0.411) | 0.312 | 148,632 | 2.6 (13.46) | 2.3E-08 | 104,263 | ||
Abbreviations; Pos, Position in x chromosome; A1, Effect allele; Info, Imputation quality; Freq, Frequency of effect allele based on combined samples; OR, Odd ratio; SE, Standard error; P, p-Value; N, Number of included individuals.