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. 2023 Feb 21;14:1113968. doi: 10.3389/fphys.2023.1113968

FIGURE 3.

FIGURE 3

In (A) EB integrity of HUVEC monolayers upon stimulation by serum from COVID-19 patients and healthy individuals (n = 27–30 per group). The lower the normalized resistance, the higher the magnitude of EB disruption. Significant differences (* to****) are evident from 15 min to 5 h (Anova corrected for multiple comparisons). (B) EB integrity of HULEC monolayers upon stimulation by serum from COVID-19 patients and healthy individuals (n = 8 per group). Significant differences (* to***) are evident from 15 min to 1 h (Anova corrected for multiple comparisons). In (C) and (D), we shown the correlation of EB disruption with clinically relevant outcomes such days of intensive care unit (ICU) stay and total hospital length of stay respectively. In (E) and (F), Ang-2 and VEGF-A levels was correlated with EB disruption. (n = 57–60 per group). Negative correlations (Spearman test) indicate that the magnitude of EB disruption is associated with worse outcomes. p values: * <0.05; ** <0.01; *** <0.001; **** <0.0001.