Table 1.
LncRNA-miRNA-mRNA axis regulation in teleost fish.
| Regulated biological process |
Related fish species | Related Organs/Cells | Stimulus | Mainly related lncRNAs | Mainly related miRNAs | Mainly related genes | Mainly related signaling pathways | Refs |
|---|---|---|---|---|---|---|---|---|
| Growth and development |
Ctenopharyngodon
idella |
Brain | None | MSTRG.6764; MSTRG.50349 |
miR-27a-3p; miR-206 | lpxn; axpm | Actin cytoskeleton; Ras; Chemokine; Immunity | (46) |
| Danio rerio | Embryos | None | Cyrano | miR-7 | UN | Neurodevelopment | (47) | |
|
Ctenopharyngodon
idella |
Hepatopancreas | None | MSTRG.35807; MSTRG.21503; MSTRG.25056; MSTRG.41999 |
miR-13b-5p; miR-22a-5; miR-10b-5p |
cel; amy2a; repe2; cbp1; celf1; ela3l; cpa2 | Biosynthesis; Immunity; Pancreatic secretion; Peroxisome; Ras; Nutrient metabolism |
(46) | |
|
Oncorhynchus
kisutch |
Liver; Kidney; Spleen |
None | NL | NL | NL | TGF-β; NF-κB; Cytokines; Immunity; Adherens junction |
(48) | |
|
Paralichthys
olivaceus |
Gill; Liver; Kidney; Intestine |
None | NL | NL | NL | Antigen processing and presentation; TLRs; Immunity | (49) | |
|
Paralichthys
olivaceus |
Skeletal muscle | None | TCONS_00003213; TCONS_00006684; TCONS_00023918 | miR-133-5p; miR-221-3p; miR-124-5p; | GS-010675; GS-018639; GS-016120 |
Actin cytoskeleton; Tight junction; Focal adhesion |
(50) | |
| Sparus aurata | Fast skeletal muscle | None | lncRNA20194 | miR-133; miR-206; miR-20 |
myod1 | Myoblast proliferation | (51) | |
| Oncorhynchus mykiss | Muscle | None | Omy500041161; Omy400178299 |
mir-26a; mir-4185; mir-10b-mature 3'; mir-181d-mature 5' |
GSONMT00080511001; GSONMT00041090001 | TGF-β; Protein catabolism/anabolism; Immunity |
(52) | |
| Megalobrama amblycephala | Intermuscular bone | None | LNC_017705; LNC_007210; LNC_011298 |
miR-24b-3p; miR-193b-3p | zip1; C6; MamblycephalaGen-e23275 | Osteoblast differentiation; Ca2+ deposition |
(53) | |
| Astatotilapia latifasciata | B chromosomes | None | BncRNA | miR-129-3p; miR-9-5p; miR-153a-5p |
UN | Maintenance and segregation of B chromosome | (54) | |
| Reproduction | Diplodus puntazzo | Infemale gonads | None | DP-novel-07606; DP-novel-06984; DP-novel-07767 | miR-122-1; miR-7a; miR-129; miR-125c |
XR_003984576.1; XR_003429050.1; XR_001814721.1 | Gonad maturation | (55) |
| Paralichthys olivaceus | Ovary; Testis |
None | TCONS-00021450; TCONS-00058013; TCONS-00058894 |
miR-20a; let-7; miR-82155_166 |
dnah1; dnah11; dnah12 | Steroidogenesis; Spermatogenesis | (56) | |
| Paralichthys olivaceus | Ovary; Liver |
None | LNC-001695; LNC-007947; LNC-002362; LNC-003418 |
novel_103; novel_120; novel_125; novel_167 | ARMC6; PCCA; TANC2; TNR5; MMP28 |
Steroid biosynthesis; Metabolism; Immunity; Signal transduction |
(57) | |
| Bacterial infection |
Salmo salar;
Sebastes schlegelii |
Gill; Spleen |
Aeromonas salmonicida | TCONS_00079020; LOC106564649; TCONS_00022856; LNC_00116154 |
miR-155-5p; miR-551-3p; miR-8157-3p; novel_264 |
atm; tp53; mdm4; NLRC3 |
P53; Wnt/β-catenin; mTOR; Metabolism; Immunity; Phagocytosis; TLRs; Degradation | (58, 59) |
|
Paralichthys olivaceus;
Miichthys miiuy; Nibea diacanthus; Larimichthys crocea |
Spleen; MICs; EPCs; Kidney cells |
Vibrio anguillarum | lncRNA-IRL | miR-27c-3p | IRAK4 | Pathogen recognition and killing; NF-κB; Apoptosis; Immunity |
(60, 61) | |
| Paralichthys olivaceus | Intestine; HEK293T |
Edwardsiella tarda | LNC_001979 | novel_171 | potusc2; podad1 | Autophagy; PPAR, Endocytosis; MAPK, Notch; Phagosomes; Immunity | (62) | |
| Ctenopharyngodon idella | Spleen; Muscle; Brain; Heart; Fin; Gill; CIKs |
Aeromonas hydrophila | lncRNA-WAS; lncRNA-C8807; lncRNA-SUMO3; lncRNA-HDMO13; LncRNA-ANAPC2; lncRNA-NEFM |
miR-142a-3p; miR-21; miR-451 |
ccr7; glut3; jnk; tnfaip2; npr2; hdac8 |
NF-kB; MAPK; Immunity |
(63–65) | |
| Oreochromis niloticus | Spleen; Kidney |
Streptococcus agalactiae | MSTRG.2496.2; MSTRG.204071.1; MSTRG.61707.9; MSTRG.129013.3 | miR-265; miR-574; miR-466; miR-2305; miR-7082; miR-4739 |
ON_73287; ON_86194; PB_14857; PB_1748; PB_10169; EN_09656 |
Cytokines; TLRs; Endocytosis; Lysosomal metabolic; Immunity |
(66) | |
| Epinephelus coioides | Spleen | Pseudomonas plecoglossicida | c115058_g1-i1; c125321_g1-i1; c132960_g1-i1; C202650_g1-i1 |
miR-731; miR-16b; miR-375; miR-15a-3p |
cela1; cela2; ctrb; prss |
Immunity; Chemokine; Cytokine; Antigen processing and presentation | (67–70) | |
| Viral infection | Miichthys miiuy | Liver; Spleen, Kidney; Brain, Heart; Gill; Intestine; MICs | SCRV | AANCR; MARL; NOD1; NARL; MIR2187HG; MIR122HG | miR-210; miR-122; miR-217-5p; miR-2187-3p; miR-122-5p |
MITA; MAVS; NOD1; TBK1; TAK1 |
Cell proliferation; NF-κB; IRF3; Immunity |
(71–75) |
| Salmo salar | Gill | POMV | MSTRG.13941.1 | miRNA-30e-3-3p | selja | Selenium transport | (76) | |
| Others |
Oreochromis niloticus;
Oncorhynchus mykiss |
Brain; Skin; Heart; Gill; Intestine; Head kidney; ...... |
Hypoxia; Cold; Alkalinity; Salinity; Acute heat; ...... |
TCONS_00151992; MSTRG.11484.2; MSTRG.32014.1; MSTRG.29012.1 |
miR-128-5p; C-5p-43254_34; PC-3p-28352_70; bta-miR-11987_L-1R-1_1ss8TA |
ifih1; dhx58; irf3 | MAPK; Phagosome; Immunity; NOD-like receptor; RIG-I-like receptor, ...... |
(77–79) |
NL, not listed; UN, unknown.