Fig. 8. The TRPM7 channel tunes endothelial glycolysis and cell growth in vitro via SLC2A3.
A RT-qPCR of SLC2A3 in TRPM7 siRNA- or NC-transfected human umbilical vein endothelial cells (HUVECs). B–E Defective glycolysis and ATP production in TRPM7 knockdown (KD) HUVECs. F–G Decreased cell counts and suppressed cell cycle in TRPM7KD HUVECs. H Impaired tube formation in TRPM7KD HUVECs staining with lipophilic carbocyanine dye (scale bars, 250 μm). Two groups of samples were compared by unpaired two-tailed Student’s t-test.