Table 2.
Clinical features and management of pneumonitis.
| Overall (n = 53) | |
|---|---|
| CT pattern of pneumonitis | |
| Diffuse alveolar damage | 4 (8) |
| Nonspecific interstitial pneumonia | 5 (9) |
| Hypersensitivity pneumonitis | 9 (17) |
| Organizing pneumonia | 33 (62) |
| Simple pulmonary eosinophilia | 2 (4) |
| Extent of pneumonitis | |
| < 25% | 27 (51) |
| 25–50% | 17 (32) |
| > 50% | 9 (17) |
| Initial CTCAE grade | |
| 1 | 23 (43) |
| 2 | 20 (38) |
| 3 | 8 (15) |
| 4 | 2 (4) |
| Worst CTCAE grade | |
| 1 | 12 (23) |
| 2 | 26 (49) |
| 3 | 8 (15) |
| 4 | 3 (6) |
| 5 | 4 (8) |
| Worsening of CTCAE grade | 17 (32) |
| Worsening of respiratory status due to pneumonitis | 12 (23) |
| Initial treatment | |
| No steroid and immunosuppressive agents | 27 (51) |
| High dose of steroid | 16 (30) |
| Low dose of steroid | 9 (17) |
| High dose of steroid + immunosuppressive agents | 1 (2) |
| Clinical outcome | |
| Improved | 45 (85) |
| Death due to infection during treatment | 2 (4) |
| Death due to cancer during treatment | 2 (4) |
| Death due to pneumonitis | 4 (8) |
| Worsening of PS after the improvement* | 8 (18*) |
Abbreviations: CT computed tomography, CTCAE Common Terminology Criteria for Adverse Events.
*Among the 45 patients who improved.