Table 3.
Without worsening (n = 41) | With worsening (n = 12) | p value | |
---|---|---|---|
Age (years) | 0.76 | ||
Median (range) | 69 (44–81) | 67.5 (31–84) | |
Sex, n (%) | 0.051 | ||
Male | 30 (73) | 12 (100) | |
Smoking status, n (%) | 0.32* | ||
Current | 18 (44) | 5 (42) | |
Former | 16 (39) | 7 (58) | |
Never | 7 (17) | 0 (0) | |
ECOG PS just before pneumonitis, n (%) | 0.07* | ||
0 | 15 (37) | 2 (17) | |
1 | 24 (59) | 7 (58) | |
2 | 2 (5) | 1 (8) | |
3 | 0 (0) | 2 (17) | |
Initial CTCAE grade of pneumonitis | < 0.001* | ||
1 | 22 (54) | 1 (8) | |
2 | 17 (41) | 3 (25) | |
3 | 2 (5) | 6 (50) | |
4 | 0 (0) | 2 (17) | |
CT pattern of pneumonitis | 0.002* | ||
DAD | 0 (0) | 4 (33) | |
HP | 6 (15) | 3 (25) | |
NSIP | 5 (12) | 0 (0) | |
OP | 28 (68) | 5 (42) | |
Simple PEo | 2 (5) | 0 (0) | |
Extent of pneumonitis | 0.009* | ||
< 25% | 25 (61) | 2 (17) | |
25–50% | 12 (29) | 5 (42) | |
> 50% | 4 (10) | 5 (42) | |
Pre-existing interstitial lung disease, n (%) | 4 (10) | 2 (17) | 0.61 |
Emphysema, n (%) | 25 (61) | 10 (83) | 0.18 |
Previous thoracic radiotherapy, n (%) | 4 (10) | 3 (25) | 0.18 |
Abbreviations: ECOG PS Eastern Cooperative Oncology Group Performance Status, CTCAE Common Terminology Criteria for Adverse Events, CT computed tomography, DAD diffuse alveolar damage, HP hypersensitivity pneumonitis, NSIP nonspecific interstitial pneumonia, OP organizing pneumonia, PEo pulmonary eosinophilia.
*Comparison between smokers and never-smokers, performance status (PS) 0–1 and PS 2–3, grades 1–2 and grades 3–4, DAD and others, and ≥ 25% and < 25%.