Table 2.
Clinical and laboratory parameters among SCD patients 1 month before, during, and 1 month after Ramadan.
| Item | Normal range | 1 month before | During | 1 month after | p-value | |
|---|---|---|---|---|---|---|
| Number of VOC | Mean (SD) | 0.21 (0.41) | 0.27 (0.45) | 0.23 (0.43) | 0.715 | |
| Number of hemolytic crises | Mean (SD) | 0.08 (0.27) | 0.13 (0.35) | 0.13 (0.35) | 0.535 | |
| Length of hospital stay (days) | Mean (SD) | 1.12 (2.4) | 1.37 (3.52) | 0.88 (1.88) | 0.623 | |
| The total dose of morphine (mg) | Mean (SD) | 24.8 (59.0) | 15.8 (55.0) | 7.12 (16.96) | 0.182 | |
| Use of antibiotics | Yes (n, %) | 6 (11.5) | 7 (13.5) | 10 (19.2) | 0.486* | |
| No (n, %) | 46 (88.5) | 45 (86.5) | 42 (80.8) | |||
| The need for exchange transfusion | Yes (n, %) | 3 (5.8) | 2 (3.8) | 1 (1.9) | 0.607* | |
| No (n, %) | 49 (94.2) | 50 (96.2) | 51 (98.1) | |||
| Admission to ICU | Yes (n, %) | 3 (5.8) | 2 (3.8) | 1 (1.9) | 0.607* | |
| No (n, %) | 49 (94.2) | 50 (96.2) | 51 (98.1) | |||
| Number of ICU days | Mean (SD) | 0.13 (0.63) | 0.12 (0.51) | 0.00 (0.00) | 0.596 | |
| WBC count × 103/μL | 4–10 | Mean (SD) | 8.62 (3.66) | 7.75 (3.03) | 9.07 (4.76) | 0.212 |
| Hb (g/dL) | 13–17 | Mean (SD) | 9.86 (1.50) | 9.74 (1.91) | 9.97 (1.49) | 0.761 |
| Platelet count × 103/μL | 150–410 | Mean (SD) | 271.39 (138.92) | 234.35 (104.40) | 317.08 (158.90) | 0.003 |
| Reticulocytes count × 103/ μL | 50–100 | Mean (SD) | 198.84 (76.23) | 150.34 (55.58) | 197.36 (77.17) | < 0.001 |
| Urea (mmol/L) | 2.5–7.8 | Mean (SD) | 2.85 (1.31) | 3.08 (0.98) | 6.04 (10.95) | 0.098 |
| Creatinine (μmol/L) | 62–106 | Mean (SD) | 65.69 (2.42) | 67.90 (19.35) | 60.38 (22.05) | 0.038 |
| Bilirubin (μmol/L) | 0–21 | Mean (SD) | 33.89 (26.10) | 25.27 (13.88) | 31.87 (24.35) | 0.063 |
| LDH (U/L) | 105–333 | Mean (SD) | 365.89 (150.12) | 355.67 (153.83) | 444.00 (136.03) | NA** |
SCD, Sickle cell disease; VOC, Vaso-occlusive crisis; ICU, intensive care unit; WBCs, White blood cells; Hb, Hemoglobin; LDH, Lactate dehydrogenase; NA, not available; (*), One-way with repeated measures ANOVA with a Greenhouse-Geisser correction ± Friedman tests were used; (**), unavailability of LDH values for most of the cases in the three time periods did not allow for analysis of this variable.