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. 2023 Feb 21;14:1135516. doi: 10.3389/fphar.2023.1135516

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Copyright © 2023 Zhou, Nagashima, Toda, Kobayashi, Suzuki, Nagayasu, Shirakawa, Asai and Kaneko.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased incidence of dyslipidemia with the prescription of drugs and confounding effects of concomitant drugs on the olanzapine-induced dyslipidemia in FDA Adverse Event Reporting System (FAERS) data. Volcano plots for visualizing the reporting odds ratio (ROR, on a log scale) and its statistical significance (absolute Z-score) are shown. Each circle indicates an individual drug, and the size of the circle reflects the number of patients taking the drug. (A) Strong and significant increases in the ROR for dyslipidemia were seen in patients using olanzapine. (B) Within the population taking olanzapine, confounding effects of concomitantly used drugs on the incidence of olanzapine-induced dyslipidemia were calculated thoroughly and plotted. Overall values are presented in (Supplementary Tables S2, S3).