Table 2.
Associations between polygenic risk scores and suicidal feelings in a population-based sample of older adults (n = 3,019).
| Major depression included | Major depression excluded | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GWAS-level (n: SNPs) | 95% CI | 95% CI | ||||||||||
| Trait | Score-id | Beta | SE | Lower | Upper | p-value | Beta | SE | Lower | Upper | p-value | |
| Suicide attempts | Erlangsen_2020 | 1e-6 (n: 4) | −0.049 | 0.0526 | −0.152 | 0.054 | 0.4 | −0.060 | 0.0613 | −0.180 | 0.061 | 0.3 |
| Suicidality broad | Strawbridge_2019 | 5e-8 (n: 3) | 0.059 | 0.0563 | −0.051 | 0.169 | 0.3 | 0.066 | 0.0655 | −0.062 | 0.195 | 0.3 |
| Depression | gwc-GCST007342 | 5e-8 (n: 69) | 0.171 | 0.0588 | 0.056 | 0.286 | 0.004* | 0.182 | 0.0673 | 0.050 | 0.314 | 0.007* |
| Major depressive disorder | gwc-GCST006041 | 5e-8 (n: 11) | 0.156 | 0.0529 | 0.052 | 0.259 | 0.003* | 0.155 | 0.0579 | 0.042 | 0.269 | 0.007* |
| Depressive symptoms | gwc-GCST007340 | 5e-8 (n: 137) | 0.114 | 0.0595 | −0.003 | 0.231 | 0.06 | 0.111 | 0.0683 | −0.023 | 0.245 | 0.1 |
| Depression (broad) | ebi-a-GCST005902 | 1e-5 (n: 167) | 0.175 | 0.0692 | 0.039 | 0.310 | 0.01* | 0.137 | 0.0800 | −0.020 | 0.294 | 0.09 |
| Depression (broad) | ebi-a-GCST005902 | 5e-8 (n: 22) | 0.079 | 0.1024 | −0.122 | 0.280 | 0.4 | 0.100 | 0.1171 | −0.130 | 0.329 | 0.4 |
| Major depressive disorder | ieu-a-1,187 | 1e-5 (n: 201) | 0.069 | 0.0569 | −0.042 | 0.181 | 0.2 | 0.051 | 0.0643 | −0.075 | 0.177 | 0.4 |
| Major depressive disorder | ieu-a-1,187 | 5e-8 (n: 39) | 0.114 | 0.0555 | 0.005 | 0.223 | 0.04 | 0.145 | 0.0648 | 0.018 | 0.272 | 0.03 |
| Depression ever diagnosed | ukb-d-20544_11 | 1e-5 (n: 40) | 0.038 | 0.0884 | −0.136 | 0.211 | 0.7 | 0.098 | 0.1006 | −0.099 | 0.295 | 0.3 |
| Depression ever diagnosed | ukb-d-20544_11 | 5e-8 (n: 6) | −0.031 | 0.1156 | −0.257 | 0.196 | 0.8 | 0.068 | 0.1341 | −0.195 | 0.331 | 0.6 |
| Alzheimer’s disease | Kunkle_2019 | 1e-5 (n: 66) | −0.090 | 0.0611 | −0.210 | 0.029 | 0.1 | −0.083 | 0.0699 | −0.220 | 0.054 | 0.2 |
| Alzheimer’s disease | Kunkle_2019 | 5e-8 (n: 25) | −0.073 | 0.0628 | −0.196 | 0.050 | 0.2 | −0.055 | 0.0715 | −0.195 | 0.085 | 0.4 |
| Cognitive performance | ebi-a-GCST006572 | 1e-5 (n: 680) |
−0.199 | 0.0580 | −0.312 | −0.085 | 0.0006* | −0.221 | 0.0655 | −0.349 | −0.093 | 0.0007* |
| Cognitive performance | ebi-a-GCST006572 | 5e-8 (n: 205) | −0.171 | 0.0586 | −0.286 | −0.056 | 0.004* | −0.168 | 0.0672 | −0.299 | −0.036 | 0.01* |
| Educational attainment | gwc-GCST006442 | 5e-8 (n: 498) | −0.008 | 0.0527 | −0.111 | 0.095 | 0.9 | 0.017 | 0.0595 | −0.100 | 0.133 | 0.8 |
| Neuroticism | ebi-a-GCST006940 | 1e-5 (n: 472) | 0.154 | 0.0566 | 0.043 | 0.265 | 0.006* | 0.149 | 0.0614 | 0.028 | 0.269 | 0.02 |
| Neuroticism | ebi-a-GCST006940 | 5e-8 (n: 114) | 0.141 | 0.0550 | 0.033 | 0.248 | 0.01* | 0.171 | 0.0607 | 0.052 | 0.290 | 0.005* |
| Neuroticism | ebi-a-GCST005232 | 1e-5 (n: 393) | 0.117 | 0.0648 | −0.010 | 0.244 | 0.07 | 0.122 | 0.0734 | −0.022 | 0.266 | 0.1 |
| Neuroticism | ebi-a-GCST005232 | 5e-8 (n: 94) | 0.111 | 0.0729 | −0.031 | 0.254 | 0.1 | 0.155 | 0.0829 | −0.007 | 0.317 | 0.06 |
| Neuroticism score | ukb-b-4,630 | 1e-5 (n: 530) | 0.128 | 0.0600 | 0.011 | 0.246 | 0.03 | 0.104 | 0.0659 | −0.025 | 0.233 | 0.1 |
| Neuroticism score | ukb-b-4,630 | 5e-8 (n: 145) | 0.110 | 0.0642 | −0.016 | 0.236 | 0.09 | 0.146 | 0.0711 | 0.007 | 0.286 | 0.04 |
| Loneliness, isolation | ukb-b-8,476 | 1e-5 (n: 123) | 0.029 | 0.0535 | −0.076 | 0.134 | 0.6 | 0.018 | 0.0632 | −0.106 | 0.142 | 0.8 |
| Loneliness, isolation | ukb-b-8,476 | 5e-8 (n: 17) | −0.058 | 0.0526 | −0.161 | 0.045 | 0.3 | −0.054 | 0.0623 | −0.176 | 0.068 | 0.4 |
| Feeling lonely | ebi-a-GCST006942 | 1e-5 (n: 87) | 0.070 | 0.0522 | −0.033 | 0.172 | 0.2 | 0.072 | 0.0598 | −0.046 | 0.189 | 0.2 |
| Feeling lonely | ebi-a-GCST006942 | 5e-8 (n: 7) | 0.024 | 0.0524 | −0.078 | 0.127 | 0.6 | 0.007 | 0.0594 | −0.110 | 0.123 | 0.9 |
| Loneliness | gwc-GCST006923 | 5e-8 (n: 9) | −0.031 | 0.0526 | −0.134 | 0.072 | 0.6 | −0.047 | 0.0600 | −0.165 | 0.070 | 0.4 |
| Ischemic stroke | ebi-a-GCST005843 | 1e-5 (n: 90) | −0.024 | 0.0544 | −0.131 | 0.083 | 0.7 | 0.019 | 0.0628 | −0.104 | 0.142 | 0.8 |
| Ischemic stroke | ebi-a-GCST005843 | 5e-8 (n: 18) | 0.002 | 0.0530 | −0.102 | 0.106 | 0.99 | 0.047 | 0.0610 | −0.073 | 0.166 | 0.4 |
| hypertension | ukb-b-12,493 | 1e-5 (n: 289) | −0.023 | 0.0585 | −0.138 | 0.091 | 0.7 | 0.011 | 0.0670 | −0.121 | 0.142 | 0.9 |
| hypertension | ukb-b-12,493 | 5e-8 (n: 80) | 0.005 | 0.0545 | −0.102 | 0.112 | 0.9 | 0.088 | 0.0621 | −0.034 | 0.210 | 0.2 |
| High blood pressure | ukb-b-14,177 | 1e-5 (n: 769) | 0.073 | 0.0573 | −0.039 | 0.185 | 0.2 | 0.111 | 0.0668 | −0.020 | 0.241 | 0.1 |
| High blood pressure | ukb-b-14,177 | 5e-8 (n: 331) | 0.019 | 0.0580 | −0.095 | 0.132 | 0.7 | 0.031 | 0.0667 | −0.100 | 0.162 | 0.6 |
| Atheroscelrotic heart disease | ukb-b-1,668 | 1e-5 (n: 108) | −0.027 | 0.0519 | −0.128 | 0.075 | 0.6 | 0.027 | 0.0585 | −0.087 | 0.142 | 0.6 |
| Atheroscelrotic heart disease | ukb-b-1,668 | 5e-8 (n: 30) | −0.009 | 0.0547 | −0.116 | 0.098 | 0.9 | 0.053 | 0.0624 | −0.069 | 0.176 | 0.4 |
| Angina | ukb-b-8,468 | 1e-5 (n: 91) | 0.075 | 0.0554 | −0.033 | 0.184 | 0.2 | 0.093 | 0.0637 | −0.032 | 0.218 | 0.1 |
| Angina | ukb-b-8,468 | 5e-8 (n: 23) | 0.071 | 0.0542 | −0.035 | 0.177 | 0.2 | 0.112 | 0.0633 | −0.012 | 0.236 | 0.07 |
Significant value of ps at the level 0.05 are shown in bold. *Value of ps significant after Bonferroni correction for multiple testing (corrected p-value threshold = 0.01; based on testing of PRSs within five different domains related to suicidal feelings in old age: psychiatric disease, personality, cognitive function/performance, loneliness, vascular disease.