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. 2023 Feb 21;13:1058337. doi: 10.3389/fonc.2023.1058337

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Copyright © 2023 Kazakova, Rakina, Sudarskikh, Iamshchikov, Tarasova, Tashireva, Afanasiev, Dobrodeev, Zhuikova, Cherdyntseva, Kzhyshkowska and Larionova

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The association of stromal expression of S100A4, SPARC and SPP1 with survival and clinical-pathological parameters. (A) S100A4 stromal expression predicts poor OS for CRC patients and colon cancer patients, but is negatively correlated with tumor stage in rectal cancer. (B) The prognostic significance of S100A4 protein levels for overall survival in patients with CRC and CC revealed by univariate and multivariate COX analysis. (C) SPARC stromal expression is an unfavorable parameter for RFS in rectal cancer patients. SPARC protein expression is negatively associated with clinical-pathological parameters in combined CRC group and in rectal cancer patients. (D) SPP1 stromal expression is unfavorable for PFS in patients with rectal cancer. SPP1 protein expression is negatively associated with clinical-pathological parameters in combined CRC group and in rectal cancer patients. Log-rank test p-values are shown in Kaplan-Meier plots. Mann-Whitney U test was applied for the comparison of two groups. Box plots depict protein expression (min, Q1, median, Q3, max).