Table 1.

Worldwide In vitro and In vivo studies on EDCs exposure impact on placenta and placenta development.

EDCs	In vitro & In vivo	Experimental Model	Impact on Placentation	Authors
PBDE, OH-PBDE	In vitro	Trophoblast-derived cell line	Impaired thyroxine transport	89
BPA	In vitro	HTR-8/SVneo cell line	Proliferation and migration	90
BPA	In vitro	BeWo cell lines	Placenta (GPR30)	88
Firemaster 550	In vivo	Rat model	Placenta physiology	6
BPA	In vivo	Mouse model	Induce apoptosis in trophoblast cell	55
Homosalate	In vitro	HTR8/SVneo cell lines	Proliferation and invasiveness	91
BPA	In vivo	Mouse model	Spiral artery	53
BPA, BPS	In vivo	Pregnant sheep	Trophoblast signaling pathway	92
BPA, DEHP, PFOA	In vitro	Rhesus monkey TSC cell line	Trophoblast development and implantation	87
Methyl-Parabnan	In vivo	Pregnant mother	placental cholinergic function	93
PBDE	In vivo	Mouse model	Placental tissue signaling pathway	94
BPA, BPS	In vitro	Placenta tissue	Newborn recruited	95
BPA, Triclosan	In vitro	Human endometrial stomal cell line	Migration and decidualization	96
Phthalate, Phenol	In vitro	Pregnant women urine	Placenta (miRNA expression)	97
DEHP	In vitro	BeWo human trophoblast cell lines	Growth and invasiveness	98
Bifenthrin pesticide	In vitro	JEG-3 cell lines	Estrogen receptor pathway	99
Organochlorine	In vitro	Human trophoblast and MCF-7 cell line	Trophoblast proliferation and migration	100
Cadmium	In vitro	Human endometrial endothelial cell line	Endometrial angiogenesis	101
DDT	In vivo	Rat model	Induce apoptosis	102
Xenobiotic	In vitro	Trophoblast cell lines	Trophoblast invasion	103
DEHP	In vivo	Rat trophoblast cell line	Growth retardation	104
DDT, MTC	In vitro	JEG-3 human choriocarcinoma cell line	estrogen signaling pathways, placenta (Ca handling)	15