Comparison 2. Patient‐reported outcomes at latest follow‐up.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
2.1 Main analysis	3	176	Std. Mean Difference (IV, Random, 95% CI)	0.05 [‐0.85, 0.95]
2.1.1 Clinical	1	19	Std. Mean Difference (IV, Random, 95% CI)	0.05 [‐0.85, 0.95]
2.1.2 Preclinical	2	157	Std. Mean Difference (IV, Random, 95% CI)	Not estimable
2.2 Data for main analysis – continuous data	1	19	Std. Mean Difference (IV, Random, 95% CI)	0.05 [‐0.85, 0.95]
2.2.1 Parallel	1	19	Std. Mean Difference (IV, Random, 95% CI)	0.05 [‐0.85, 0.95]
2.3 Not in meta‐analysis	20		Other data	No numeric data
2.3.1 Insufficient data	2		Other data	No numeric data
2.3.2 No relevant data	18		Other data	No numeric data