Solomon 1960.

Study characteristics
Methods	Type: clinical Design: cross‐over Objective: to investigate psychologic and osteometabolic responses to sex hormones in elderly osteoporotic women Treatment duration: 6 weeks per cross‐over period Follow‐up duration (including treatment duration): 6 weeks per cross‐over period Washout between cross‐over periods: not stated explicitly, but probably none
Data	Country: USA Condition: women with postmenopausal osteoporosis or Paget's disease Number of people randomised: 12 randomised to a cross‐over sequence Number of people analysed: all 12 completed, but unclear if all 12 analysed for each placebo
Comparisons	Active placebo: dextroamphetamine and amobarbital (5 mg, twice daily) Standard placebo: lactose Experimental intervention: 2 groups: methallenestril (3 mg twice daily) and fluoxymesterone (5 mg twice a day) Administration: oral
Outcomes	Participant‐reported outcome: questionnaire covering 10 categories (household activities, social activities, resting, motor performance, sleeping, pain, psychological distress, well‐being, interest and participation in environment, and libidinal stimulation) Observer‐reported outcome: 24 hour urinary calcium excretion Harm outcome: none Co‐intervention outcome: none
Terminology for active placebo	"Active placebo" a priori
Scores and unpleasantness of the active placebo	Adequacy: 2 Risk of therapeutic effect: 4 Unpleasant/neutral/pleasant: unpleasant
Funding and conflicts of interest	Mixed; received drugs from companies. Conflicts of interest not reported.
Notes
Risk of bias
Item	Authors' judgement	Support for judgement
Free from risk of bias arising from the randomisation process	Unclear	Completed Latin squares design. No other information.
Free from risk of bias in selection of the reported result All outcomes	Unclear	No information.