Table 3.

Cefiderocol Dose Regimens Based on Renal Function

Renal Function	Renal Function Estimates	Dose Regimen
Augmenteda	CG-CLCR, >120 mL/min	2 g every 6 hours, 3-hour infusion
Normal	MDRD-eGFR, 90 to <120 mL/min/1.73 m2	2 g every 8 hours, 3-hour infusion
Mild impairment	MDRD-eGFR, 60 to <90 mL/min/1.73 m2	2 g every 8 hours, 3-hour infusion
Moderate impairment	MDRD-eGFR, 30 to <60 mL/min/1.73 m2	1.5 g every 8 hours, 3-hour infusion
Severe impairment	MDRD-eGFR, 15 to <30 mL/min/1.73 m2	1 g every 8 hours, 3-hour infusion
End-stage renal disease	MDRD-eGFR, <15 mL/min/1.73 m2	0.75 g every 12 hours, 3-hour infusion
Requiring intermittent hemodialysis		0.75 g every 12 hours, 3-hour infusion, with consideration for supplemental (third) dose of 0.75 g administered after hemodialysis on dialysis days [25]
Requiring continuous renal replacement therapy	Dosed based on effluent flow rate
	≤2 L/hour	1.5 g every 12 hours
	2.1 to 3 L/hour	2 g every 12 hours
	3.1 to 4 L/hour	1.5 g every 8 hours
	≥4.1 L/hour	2 g every 8 hours

Abbreviations: CG-CL_CR, Cockcroft-Gault creatinine clearance; eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease.

^aPatients with hypermetabolic states due to sepsis [31].