Table 1.
Patients with ACI.
| Therapy | APA | Argatroban + APA | DOAC | UFH | Warfarin |
|---|---|---|---|---|---|
| Patients (n) | 51 | 29 | 19 | 5 | 4 |
| Age (years) | 75.0 (64.0-79.8) |
70.0 (58.0-78.3) |
79.0 (73.3-83.0) |
83.0 (80.0-84.0) |
82.5# (73.0-84.0) |
| Sex (females:males) | 17:34 | 6:23 | 6:13 | 4:1 | 3:1 |
| Samples number | 69 | 45 | 28 | 7 | 6 |
| ACI type | Lacunar or atherosclerotic-a | Atherosclerotic-w | Cardioembolic ACI | ||
| PLT (×1010/μl) | 22.0 (19.2-28.3) |
21.8 (19.6-25.5) |
20.3 (15.0-26.8) |
21.1 (19.1-27.8) |
27.5 (CNC) |
| APTT (s) | 30.0 (28.0-32.0) |
44.0*** (33.3-52.0) |
35.0*** (32.0-39.0) |
39.0* (30.5-72.8) |
37.0** (CNC) |
| PT-INR | 0.98 (0.94-1.03) |
1.10*** (1.04-1.16) |
1.09*** (1.04-1.14) |
1.11** (1.07-1.18) |
2.29*** (CNC) |
| D-dimer (μg/ml) | 0.90 (0.50-1.68) | 0.50 (0.50-1.05) * | 1.10 (0.58-2.03) | 3.30 (CNC) * | 1.45 (CNC) |
| Fibrinogen (mg/dl) | 329 (298-427) | 326 (299-359) | 343 (281-433) | 456 (331-520) | 350 (CNC) |
Data are expressed as the median (25th-75th percentile); #, range. ACI, acute cerebral infarction; APA, antiplatelet agent; DOAC, direct oral anticoagulant; UFH, unfractionated heparin; CNC, cannot be calculated; PLT, platelet count; PT-INR, prothrombin time-international normalized ratio; atherosclerotic-a, atherosclerotic: at 48 h after the onset; atherosclerotic-w, atherosclerotic within 48 h of the onset.
***P < .001; **P < .01; *P < .05 compared with the APA group.