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. 2023 Mar 4;15:17588359231157641. doi: 10.1177/17588359231157641

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© The Author(s), 2023

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Effect of AGAMENON-HER2 covariates on PFS (a) and OS (b).

Adjusted TRs are derived from a multivariable log-normal AFT model and represent its exponentiated coefficients (Table 3). Interpretation of the adjusted TRs: TR > 1 means that an increase in the value of the covariate is associated with longer survival. TR < 1 means that an increase in the value of the covariate is associated with shorter survival. The criteria for overall tumour burden are specified in Table 1.

AFT, accelerated failure time; CAPOX, capecitabine/oxaliplatin; CEA, carcinoembryonic antigen; CI, confidence interval; ECOG PS, Eastern Cooperative Oncology Group performance status; FISH, fluorescence in situ hybridisation; FOLFOX, 5-fluorouracil/oxaliplatin; GEJ, gastroesophageal junction; HER2, human epidermal growth factor receptor-2; IHC, immunohistochemistry; OS, overall survival; PFS, progression-free survival; TRs, time ratios; XP, capecitabine/cisplatin.