Table 1.

Definitions of overall tumour burden.

Tumour burden	Definition
Low	• 1 single organ involved with 1 or 2 lesions or mild ascites/microscopic peritoneal dissemination with no other sites
Moderate	• 1 single involved organ with 3–5 lesions • 2 involved organs with <3 lesions per organ
High	• 1 single organ involved with >5 lesions • 3 or more involved organs
Very high	• Baseline sum of total diameters >15 cm • Moderate or severe ascites • Diffuse peritoneal metastases with nodules >2–3 cm • CNS metastases • 3 or more bone metastases • Liver tumour burden >50%

Mild ascites was defined as not clinically evident, diagnosed with CT or ultrasound.

CNS, central nervous system; CT, computed tomography.