Table 3.
Comparison of clinical outcomes between AOA and non-AOA after motile or immotile sperm injection.
| Group 1 | Group 2 | Group 3 | P-value | P1-value | P2-value | |
|---|---|---|---|---|---|---|
| No. of ET cycles | 155 | 100 | 87 | / | / | |
| Age (years) | 29.95 (27, 33) | 30.25 (27, 34) | 29.11 (27, 32) | 0.366 | 0.346 | 0.107 |
| Embryos per transfer | 1.51 (1, 2) | 1.56 (1, 2) | 1.41 (1, 2) | 0.131 | 0.433 | 0.057 |
| Blastocyst-stage ET rate (%) | 24.37 (58/238) | 24.84 (39/157) | 19.20 (24/125) | 0.464 | 0.915 | 0.259 |
| Implantation rate (%) | 34.87 (83/238) | 31.85 (50/157) | 28.00 (35/125) | 0.408 | 0.533 | 0.484 |
| Clinical pregnancy rate (%) | 43.87 (68/155) | 41.00 (41/100) | 34.48 (30/87) | 0.360 | 0.651 | 0.360 |
| Miscarriage rate (%) | 17.65 (12/68)a,b | 2.44 (1/41)b | 20.00 (6/30)a | 0.043* | 0.018* | 0.014* |
| Pregnancy rate of first ET (%) | 67.09 (53/79)a | 50.00 (32/64)a,b | 40.28 (29/72)b | 0.004* | 0.039* | 0.255 |
| Live birth rate (%) | 36.13 (56/155) | 40.00 (40/100) | 27.59 (24/87) | 0.194 | 0.533 | 0.074 |
| Neonatal outcomes of embryo transfer | 0.369 | 0.634 | 0.307 | |||
| Singletons (%) | 78.57 (44/56) | 82.50 (33/40) | 91.67 (22/24) | |||
| Twins (%) | 21.43 (12/56) | 17.50 (7/40) | 8.33 (2/24) | |||
| Baby’s sex | 0.030* | 0.011* | 0.606 | |||
| Birth babies | 68 | 47 | 26 | |||
| Male (%) | 39.71 (27/68)a | 63.83 (30/47)b | 57.69 (15/26)a,b | |||
| Female (%) | 60.29 (41/68) | 36.17 (17/47) | 42.31 (11/26) | |||
| Birth weight (g) | ||||||
| Singletons | 3177.84 ± 435.03 | 3175.76 ± 444.40 | 3200.45 ± 424.29 | 0.975 | 0.795 | 0.970 |
| Twins | 2220.83 ± 646.29 | 2156.64 ± 671.03 | 2358.75 ± 130.28 | 0.849 | 0.850 | 0.110 |
| Body length (cm) | ||||||
| Singletons | 49.34 (48.00, 50.75) | 50.06 (49.00, 51.00) | 50.00 (50.00, 50.25) | 0.708 | 0.607 | 0.661 |
| Twins | 46.00 (45.25, 48.75) | 44.29 (43.00, 48.00) | 47.00 (46.00, 48.00) | 0.712 | 0.455 | 0.518 |
| Early neonatal death rate (%) | 0 | 0 | 0 | |||
| Birth defect rate (%) | 0 | 0 | 0 |
Values are mean ± standard deviation; median (Quartile1, Quartile3) or percent (n).
Group 1, AOA after motile sperm injection; Group 2, non-AOA after motile sperm injection; Group 3, AOA after immotile sperm injection.
P1, Group 1 compared with group 2; P2, Group 3 compared with group 2. Focusing on P1 and P2, the comparison between group 1 and group 3 was not performed.
a,b Different superscript letters indicate statistical significance between groups (P<.05).
*Significantly different (P<.05).
AOA, assisted oocyte activation; ET, embryo transfer.