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. Author manuscript; available in PMC: 2023 Mar 7.
Published in final edited form as: Cell Rep. 2023 Jan 23;42(1):112024. doi: 10.1016/j.celrep.2023.112024

Figure 6. IsoLGs form amyloid-like p53 aggregates.

Figure 6.

(A) Dot blot analysis of CP-A cell extracts using anti-amyloid OC antibody. Protein aggregation levels were found to be higher in CP-A cells treated with ABS than in control untreated cells (***p < 0.001; n = 3; Tukey’s multiple comparison). 2-HOBA prevented amyloid aggregation (***p < 0.001; n = 3; Tukey’s multiple comparison).

(B) The same as (A) but the formation of amyloid aggregates was analyzed in EPC-2 cells.

(C) Representative images of co-localization of p53 protein with amyloid fibrils detected with anti-amyloid OC antibody in CP-A cells (n = 3) (scale bar, 5 μm). All results are expressed as mean ± SD.