Table 1.
POM121 protein expression level and GC patient clinicopathological characteristics
| Characteristics | n | POM121 expression (%) | Pearson χ2 | P-value | |
|---|---|---|---|---|---|
|
| |||||
| Low or no | High | ||||
| Total | 684 | 251 | 433 | ||
| Gender | 2.928 | 0.087 | |||
| Male | 495 | 172 (34.75) | 323 (65.25) | ||
| Female | 189 | 79 (41.80) | 110 (58.20) | ||
| Age | 0.443 | 0.506 | |||
| <60 | 256 | 98 (38.28) | 158 (61.72) | ||
| ≥60 | 428 | 153 (35.75) | 275 (64.25) | ||
| Histological type | 0.287 | 0.991 | |||
| Tubular | 485 | 180 (37.11) | 305 (62.89) | ||
| Mucinous | 89 | 32 (35.96) | 57 (64.04) | ||
| Mixed (tubular and mucinous) | 16 | 5 (31.25) | 11 (68.75) | ||
| Signet ring cell | 45 | 16 (35.56) | 29 (64.40) | ||
| Othersa | 49 | 18 (36.73) | 31 (63.27) | ||
| Differentiation | 1.281 | 0.527 | |||
| Well | 198 | 77 (38.89) | 121 (61.11) | ||
| Moderate | 261 | 89 (34.10) | 172 (65.90) | ||
| Poor | 225 | 85 (37.78) | 140 (62.22) | ||
| Depth of invasion | 17.831 | 0.001* | |||
| Tis | 23 | 14 (60.87) | 9 (39.13) | ||
| T1 | 78 | 36 (46.15) | 42 (53.85) | ||
| T2 | 138 | 57 (41.30) | 81 (58.70) | ||
| T3 | 405 | 137 (33.83) | 268 (66.17) | ||
| T4 | 40 | 7 (17.50) | 33 (82.50) | ||
| Lymph node metastasis | 5.826 | 0.120 | |||
| N0 | 258 | 93 (36.05) | 165 (63.95) | ||
| N1 | 193 | 72 (37.31) | 121 (62.69) | ||
| N2 | 117 | 52 (44.44) | 65 (55.56) | ||
| N3 | 116 | 34 (29.31) | 82 (70.69) | ||
| Distant metastasis | 7.505 | 0.006* | |||
| M0 | 573 | 223 (38.92) | 350 (61.08) | ||
| M1 | 111 | 28 (25.23) | 83 (74.77) | ||
| TNM stage | 18.412 | 0.001* | |||
| 0 | 29 | 16 (55.17) | 13 (44.83) | ||
| I | 110 | 49 (44.55) | 61 (55.45) | ||
| II | 297 | 111 (37.37) | 186 (62.63) | ||
| III | 183 | 64 (34.97) | 119 (65.03) | ||
| IV | 65 | 11 (16.92) | 54 (83.08) | ||
| Preoperative CEA, ng/ml | 4.347 | 0.114 | |||
| <5 | 272 | 87 (31.99) | 185 (68.01) | ||
| ≥5 | 373 | 149 (39.95) | 224 (60.05) | ||
| Unknownb | 39 | 15 (38.46) | 24 (61.54) | ||
| Preoperative CA199, ng/ml | 5.007 | 0.082 | |||
| <37 | 246 | 96 (39.02) | 150 (60.98) | ||
| ≥37 | 301 | 116 (38.54) | 185 (61.46) | ||
| Unknownb | 137 | 39 (28.47) | 98 (71.53) | ||
| Helicobacter pylori | 0.451 | 0.502 | |||
| Positive | 420 | 150 (35.71) | 270 (64.29) | ||
| Negative | 264 | 101 (38.26) | 163 (61.74) | ||
| Her-2 | 6.285 | 0.012* | |||
| Negative | 561 | 218 (38.83) | 343 (61.14) | ||
| Positive | 123 | 33 (26.83) | 90 (73.17) | ||
a
others include: papillary adenocarcinoma 12 cases; adeno-squamous carcinoma 10 cases; squamous cell carcinoma 9 cases; undifferentiated carcinoma 8 cases; neuroendocrine carcinoma 10 cases.
b
Two unknown groups had no exact records, and thus, were not used in the P-value calculation.
*
P<0.05.