Table 1.
Relationship between HMGB1 expression and clinical features in neuroblastoma
| Clinicopathologic features | Low expression n = 6 (%) | High expression n = 6 (%) | a P-value |
|---|---|---|---|
| HMGB1 | 8.8 (6.6-11.3)b | 15.9 (12-18.8) | 0.0022 |
| Age (months) | 36.5 (21-118) | 56 (29-120) | 0.3095 |
| Gender | |||
| Male | 4 (66.7%) | 4 (66.7%) | > 0.9999 |
| Female | 2 (33.3%) | 2 (33.3%) | |
| Tumor Size (cm) | |||
| < 1 cm | 3 (50.0%) | 1 (16.7%) | 0.5455 |
| ≥ 1 cm | 3 (50.0%) | 5 (83.3%) | |
| Lymph node metastasis | |||
| Yes | 4 (66.7%) | 5 (83.3%) | > 0.9999 |
| No | 2 (33.3%) | 1 (16.7%) | |
| Bone marrow metastasis | |||
| Yes | 0 (0%) | 6 (100%) | 0.0079 |
| No | 6 (100%) | 0 (0%) | |
| Clinical stage | |||
| I+II | 5 (83.3%) | 1 (16.7%) | 0.0400 |
| III+IV | 1 (16.7%) | 5 (83.3%) | |
| MYCN | |||
| Positive | 0 (0%) | 5 (83.3%) | 0.0152 |
| Negative | 6 (100%) | 1 (16.7%) | |
| NSE (μg/L) | 33.9 (8.5-59.32) | 231.3 (81.7-370) | 0.0022 |
| VMA (μmol/d) | 18.35 (11-72.8) | 112.8 (40.3-189.7) | 0.0087 |
| LDH (U/L) | 273.5 (224-548) | 691.5 (414-1489) | 0.0108 |
HMGB1, High Mobility Group Box 1; NSE, Neuron Specific Enolase; VMA, Vanillylman Acid; LDH, Lactate Dehydrogenase.
a
P-value in Mann-Whitney U test;
b
values shown as median minimum-maximum.