Table 2.

Target kinase interaction profiles of tyrosine kinase inhibitors used in this study

Drug	Provider	Major known kinase targets
Avapritinib (BLU-285)	Selleck Chemicals	KIT, PDGFRA
Nintedanib (BIBF-1120)	Selleck Chemicals	KIT, PDGFRA, PDGFRB, FGFR, FLT3, VEGFR1, VEGFR2, LCK, LYN, SRC
Midostaurin (PKC412)	LC Laboratories	KIT, PKC, VEGFR2, PDGFRA, PDGFRB, FLT3

Abbreviations: PDGFRA/B, Platelet-Derived Growth Factor Receptor Alpha/Beta; FGFR, Fibroblast Growth Factor Receptor; FLT3, FMS-Like Tyrosine Protein Kinase-3; VEGFR, Vascular Endothelial Growth Factor Receptor; LCK, Lymphocyte-specific Protein Tyrosine Kinase; LYN, Lck/Yes Novel Tyrosine Kinase; SRC, Proto-Oncogene Tyrosine-Protein Kinase SRC; PKC, Protein Kinase C.