Table 6.
Overview of cooperative (additive versus synergistic) drug effects on growth of human MC lines
| Cooperative effects with cladribine (2CdA) produced with | ||
|---|---|---|
|
| ||
| Avapritinib | Nintedanib | |
| HMC-1.1 | + | + |
| HMC-1.2 | + | - |
| ROSAKIT WT | ± | ± |
| ROSAKIT D816V | ± | ± |
| ROSAKIT K509I | ± | ± |
| MCPV-1.2 | ± | ± |
| MCPV-1.4 | ± | ± |
Cooperative drug effects on growth of MC line were determined by measuring uptake of 3H-thymidine. Cooperative effects were calculated by Calcusyn software. Drug interactions: +: synergistic effects, CI value <1; ±: additive effects, CI value =1; -: no cooperative effects, CI value >1. Abbreviation: MC, Mast Cells.