Fig. 4.
Representative nanostructured delivery system based on MOFs. (A) The RBC membranes coating protected biomimetic O2@UiO-66@ICG@RBC from attacking by the immune systems, enhancing the EPR effect. Under laser irradiation, the RBC membrane was degraded to release ICG and UiO-66, and ICG promoted O2 release from UiO-66 thus enhancing PDT. Reproduced from [80] with permission from Elsevier Ltd.. (B) MEM@Catalast@gox@PCN-224 escaped from the immune recognition and targeted tumor cells through CCm. CAT catalyzed endogenous H2O2 to generate O2, while GOx decomposed glucose in tumor tissues, facilitating the synergistic therapeutic effects of starvation therapy and PDT. Reproduced from [81] with permission from American Chemical Society.